Figure 4. Neuronal function transcripts are regulated with aging. Two of the 10 neuronal function–related transcripts that we have previously observed to be upregulated in the retina of a rat model of Type I diabetes were significantly altered with age. Polycomb group ring finger 1 (Pcgf) increased with age while glutamate receptor ionotropic NMDA 2A (Grin2a) decreased in Adult animals and increased in the Aged animals. One-way ANOVA (ANOVA) with Benjamini-Hochberg multiple testing correction, #p<0.05; SNK post-hoc test, *p<0.05, **p<0.01, ***p<0.001, n=5/group. Error bars represent standard error of the mean.